In CD133+ cells, silencing BMI1 did not significantly alter the expression of 3 genes (ANK3, FGFR2 and CES1) that were down-regulated by over-expressed BMI1, nor the 8 genes that were up-regulated by activated BMI1 [39] in any of the 3 GBM models. This evidence concerns the gene CES1 and glioblastoma.