PARP1 and colorectal carcinoma: Interestingly, in normal colon tissue of AD patients the amount of PARP-1 protein was lower than in normal colon of CRC patients (0.66, range 0.2–1.2 in AD patients versus 2.4, range 1.0–4.0 in CRC patients, p = 0.00001, Fig. 3B).