In T-ALL, in addition to inflammatory cytokine stimulation, abnormal activation of T-cell receptor signaling, constitutive activation of Notch signaling and the inactivation of Pten signaling, all due to mutations in key components of these signal pathways, are major causes leading to the activation of NF-κB signaling in tumor cells [11], [12]. This evidence concerns the gene NFKB1 and neoplasm.