In T-ALL, in addition to inflammatory cytokine stimulation, abnormal activation of T-cell receptor signaling, constitutive activation of Notch signaling and the inactivation of Pten signaling, all due to mutations in key components of these signal pathways, are major causes leading to the activation of NF-κB signaling in tumor cells [11], [12]. The gene discussed is NFKB1; the disease is acute lymphoblastic leukemia.