ATG16L1 and colorectal carcinoma: Moreover, predicted target genes included autophagy core genes; hsa-miR-302a-3p targets ULK1 and hsa-miR-548ah-5p targets ATG16L1, suggesting that these four miRNAs participate in the autophagy process in 5-FU treatment and have the potential to be used to manipulate autophagy in 5-FU based chemotherapy in CRC.