PRSS1 and alcohol dependence: For patients without high risk factors, the current consensus is that alcoholism, biliary pancreatitis, gene mutations [serine protease inhibitor, CFTR (cystic fibrosis transmembrane conductance regulator) gene; protease, serine, 1 (trypsin 1); and serine peptidase inhibitor, Kazal type 1], idiopathic pancreatitis, irregular lifestyles, and autoimmune diseases may be the causes of CP.19