Abnormal DNA methylation has also been observed in UC patients in the estrogen receptor (ER), P14ARF, and E-cadherin gene.7 Recently, Cooke et al8 reported several genes which showed significant evidence of differential methylation both in UC and CD and many more than expected by chance overlapped with genes that were previously implicated in IBD susceptibility in GWAS. The gene discussed is ESR1; the disease is inflammatory bowel disease.