Serum C-Reacting Protein (CRP) and less so fecal calprotectin are widely used biomarkers in assessing the activity of IBD and following the course of the disease, but both lack specificity whereas their sensitivity is questionable in limited disease.16 Methylation levels, as shown already in previous studies, may be more closely and specifically related to disease activity and thus play a role as a more reliable biomarker.17–20. Here, CRP is linked to inflammatory bowel disease.