In phase II trials, it has been reported that combination chemotherapy of gemcitabine and capecitabine had some efficacy against cholangiocarcinoma and its toxicities was mild.14 Here, we performed immunohistochemical staining before starting chemotherapy and found that both the case was as strong positive immunoreactivity to TP as the TP expressions in gastric cancer.15 We used the same criteria as we used in gastric cancer in the previous report.15 The percentage of the positive cell of both case were more than 30%. The gene discussed is TYMP; the disease is gastric cancer.