In addition, it has been reported that TP expression can be a predictive marker for oral 5-FU prodrug, which will be converted to 5-FU by TP.16,17 The treatment efficacy of doxifluridine was actually proven in gastric cancer, colon cancer, and other digestive tract cancers.10,11 These finding supports our therapeutic plan. Here, TYMP is linked to malignant colon neoplasm.