Nevertheless, with longest history, the 22 years’ experience (1962–1984) proved an efficacy in tumor control and acceptable toxicity in the pre-PSA era using two-dimensional technique.7 This so called “extreme” hypofractionation (total 35–50 Gy in 4–6 fractions) was discarded for another decade until the application of high dose-rate brachytherapy in 1990s. Here, KLK3 is linked to neoplasm.