Several genes at chromosomal locus 5p15.33, including cleft lip and palate trans-membrane 1-like (CLPTM1L), were found to be associated with lung cancer risk in recent genome-wide association studies.4–8CLPTM1L, also known as CRR9, encodes an enzyme that may be associated with apoptosis.9 This gene is expressed in cells of various tumor types, including lung tumor tissue, and is overexpressed in cisplatin-resistant cell lines. The gene discussed is CLPTM1L; the disease is lung carcinoma.