The corresponding RRs to OS were: 1.51 for age over 65 years, 2.23 for HCV infection, 2.67 for liver cirrhosis, 2.98 for serum AFP over 400 ng/L, 2.17 for major resection, 1.51 for non-anatomical resection, 4.68 for blood loss over 3000 mL, 3.12 for blood transfusion, 5.74 for macroscopic and 1.62 for microscopic vascular or bile duct invasion, and 1.89 for cancer cell dominant differentiation. The gene discussed is AFP; the disease is cancer.