RASSF1 and melanoma: It has for instance been reported that the epithelioid melanoma cell type (versus all other cell types) is the most powerful independent predictor of both RASSF1A and p16 promoter hypermethylation.34 Interestingly, it was observed that BRAFV600E-mutant melanoma more often harbored a purely epithelioid cell population that was particularly evident in the distant metastases subgroup.