For example, promoter polymorphisms of the MMP-2 gene −1306 C/T and −790 T/G have been associated with the presence of CAD in a meta-analysis of 9 studies78 including a study conducted by our research group which compared patients with 3VD to controls.36 The genetic variation of RAAS has also been extensively studied in cardiovascular research. This evidence concerns the gene MMP2 and coronary artery disorder.