IL6 and kidney failure: In patients presenting with acute coronary syndrome, the G allele was found to have detrimental effects on 1-year survival.76 On the other hand, in another study including 218 patients with chronic CAD and renal failure, subjects carrying the G allele had a significantly better prognosis which was found to be consistent with our results.77 It is possible that mildly elevated IL-6 levels in −597 G to −174 G carriers could be beneficial due to their support of angiogenesis in chronic 3VD, while the increased risk of plaque destabilization is more important after acute coronary syndrome.