In patients presenting with acute coronary syndrome, the G allele was found to have detrimental effects on 1-year survival.76 On the other hand, in another study including 218 patients with chronic CAD and renal failure, subjects carrying the G allele had a significantly better prognosis which was found to be consistent with our results.77 It is possible that mildly elevated IL-6 levels in −597 G to −174 G carriers could be beneficial due to their support of angiogenesis in chronic 3VD, while the increased risk of plaque destabilization is more important after acute coronary syndrome. This evidence concerns the gene IL6 and Renal insufficiency.