In the Asia-Pacific region, most HBV infection is acquired by vertical transmission at birth, while HCV infection is acquired later in life.15 Contrary to previous report, elderly patients in this study were more frequently associated with symptomatic HCC and had more advanced BCLC staging.6 However, elderly HCC patients were less often associated with advanced tumor factors, including lower serum AFP level, lower CLIP score, smaller number of tumor(s), fewer vascular invasion, and smaller TTV. This evidence concerns the gene AFP and hepatocellular carcinoma.