For instance, approximately 50% to 60% of AFH lesions coexpress desmin, EMA, CD68, and CD99 but are generally negative for keratins, S-100 protein, CD34, and follicular dendritic cell markers (CD21 and CD35).2 Cytogenetic analysis of our case demonstrated positivity for desmin, CD68, and CD99. This evidence concerns the gene CD99 and histiocytoma, Angiomatoid fibrous.