CREB1 and histiocytoma, Angiomatoid fibrous: Besides the EWSR1 gene rearrangement detected in 4 cases by FISH, EWSR1-CREB1 fusion was confirmed in 9 cases, including a schwannoma-like AFH, and a EWSR1-ATF1 fusion was detected in a myoepithelioma-like AFH.16 These studies suggest that combinatorial FISH and RT-PCR will likely be diagnostically powerful tools to identify AFH by evaluating EWSR1-CREEB1, EWSR1-ATF1, or FUS-ATF1 fusions.2