CR2 and histiocytoma, Angiomatoid fibrous: For instance, approximately 50% to 60% of AFH lesions coexpress desmin, EMA, CD68, and CD99 but are generally negative for keratins, S-100 protein, CD34, and follicular dendritic cell markers (CD21 and CD35).2 Cytogenetic analysis of our case demonstrated positivity for desmin, CD68, and CD99.