These CKs were previously associated with worse prognosis, poorer pathologic differentiation grade, tumor recurrence, and metastasis to lymph nodes in OSCC.50–52 Thus, the PROX1 gene may contribute in the differentiation of OSCC by downregulating these CKs because differentiated cells did not express CK18 and CK19. The gene discussed is PROX1; the disease is neoplasm.