PROX1 and lip and oral cavity carcinoma: In summary, our results provide evidence that PROX1 is differentially expressed between nontumoral margins and OSCC, its overexpression reduces proliferative activity and contributes to the differentiation of OSCC cells, and its amplification is related to better prognosis of OSCC samples, suggesting that the downregulation of this gene in oral cancer contributes to the malignant phenotype.