Decreased expression of PROX1 was also found in other types of tumors as lymphomas, sporadic breast cancer, hematological malignancies, and carcinomas of the liver, biliary duct, and pancreatic biliary system.22–24,38,39 In hepatocellular carcinomas, reduced PROX1 expression is associated with poorly differentiated tumors and worst prognosis.18 This study did not find association of PROX1 expression levels with prognosis and survival in OSCC. This evidence concerns the gene PROX1 and lymphoma.