Paradoxically, the fact that HBV integrations in the FN1 loci does not occur in tumor samples implies that FN1 is not simply prone to random HBV integrations; HBV-FN1 fusion transcripts may play important roles in liver fibrosis or cirrhosis, or may enhance cancer development of cells proximate to those with HBV-FN1 fusions. The gene discussed is FN1; the disease is cancer.