GBA1 and Gaucher disease: Similarly, a recent study revealed that mutations in the glucocerebrosidase (gba) gene, causing Gaucher disease, the most common lysosomal storage disorder (LSD), resulted in impairment of mitophagy in neurons and astrocytes alike.42 Another study provided more direct evidence on the contribution of dysfunctional astrocytes in a severe LSD caused by mutations in the sulphatase modifying factor 1 (SUMF1) gene.