In addition, the growth inhibition of bladder cancer cells could be partially attributed to the dysfunction of protein quality control systems which causes cancer cells failed to prevent mitochondrial proteotoxicity due to deficiency of Lon protease and the decreased chaperone activity of Lon, which resulting in the pernicious accumulation of misfolded, unassembled and/or oxidatively damaged proteins [21,37]. This evidence concerns the gene LONP1 and urinary bladder cancer.