In the background of ductal carcinoma in situ (DCIS) of the breast, Van Bockstal et al reveal that the function of decorin is involved in breast cancer cell spreading and that both TGFβ1 and bFGF down-regulated the ECM protein decorin in CAF-associated breast tumors [5]. This evidence concerns the gene TGFB1 and ductal breast carcinoma in situ.