For instance, it has now been demonstrated in preclinical models that insulin, urocortin, atorvastatin, bradykinin, opioid receptor agonists, atrial natriuretic peptide (ANP), and Glucagon-Like Peptide-1, reduce myocardial infarct size when administered at the time of myocardial reperfusion through the activation of the RISK pathway [24]. This evidence concerns the gene NPPA and infarction.