We also characterized several AD-related targets; however, the molecules involved in the deposition of Aβ (APP, BACE1, Aβ40, and Aβ42) and tau-related kinases (CDK5, GSK3β, JNK, p38, and ERK) were not significantly altered in the older B6 mice (data not shown). This evidence concerns the gene BACE1 and Alzheimer disease.