The MP diet alleviated the cognitive impairment associated with increases in serum GSH, BDNF, the NR2A/NR2B ratio, calbindin, neurotransmitter neurons, and hippocampal neurons and decreases in serum IL-6 level, activated glia, pp38, COX2, p-tau (S202/S262), Aβ42, and BACE1 in the hippocampus of 3×Tg-AD mice. Here, GRIN2A is linked to Cognitive impairment.