In this study, the MP diet restored the spatial memory retrieval associated with increasing levels of the NR2A/NR2B ratio, cholinergic neurons in MS/DB, serotonergic neurons in the Raphe nucleus, noradrenergic neurons in the LC region, and calcium-binding protein calbindin D28K in the DG subregion of the hippocampus of 3×Tg-AD mice. This evidence concerns the gene CALB1 and Alzheimer disease.