Albumin and alpha-1 globulins were decreased while creatinine, alpha-2 globulins, urine dipstick protein, leukocyte esterase (leukocytes), hemoglobin and red blood cells were all increased in both COL4A3−/− groups compared to WT, thereby confirming the presence of glomerulosclerosis. This evidence concerns the gene ALB and glomerulosclerosis.