HOXD8 and familial pancreatic carcinoma: For example, miR-196a promotes pancreatic cancer progression by targeting nuclear factor kappa-B-inhibitor alpha [24]; miR-196a promotes non-small cell lung cancer cell proliferation and invasion through targeting HOXA5 [23]; miR-196a promotes cervical cancer proliferation through the regulation of FOXO1 and p27Kip1 [25]; miR-196a promotes CRC cell detachment, migration, invasion and chemosensitivity towards platin derivatives via regulating HoxA7, HoxB8, HoxC8 and HoxD8 [16].