SAA1 and rheumatoid arthritis: The strengths are as follows: (1) relatively large sample of consecutive patients with RA, treated in our department, (2) the detailed characteristics of patients, who have been considered in all aspects of RA pathology including several inflammatory, CV, metabolic parameters, and assessment of renal function, (3) the design of the study which was based on clinical practice, and (4) according to our knowledge being the first study which evaluates the potential association of high SAA level with QTc shortening, increasing the risk of serious arrhythmias and sudden death.