INPPL1 and neoplasm: As one of the important lipid phosphatases that act downstream of phosphoinositide-3′ kinase (PI3K), SHIP2 converts phosphatidylinositol (3,4,5)-trisphosphate (PIP3) into phosphatidylinositol (3,4)-biphosphate (PIP2) and subsequently reduces the activation of PI3K/Akt signaling cascade, which exerts energetic function in tumor development and progression [14–16].