INPPL1 and metastatic malignant neoplasm in the lymph nodes: In addition, high SHIP2 protein expression, lymph node metastasis, distant metastasis, and TNM stage were revealed to be correlated with overall survival of CRC patients by univariate analysis while high SHIP2 expression and distant metastasis were further authenticated as independent predictors for unfavorable overall survival of CRC by multivariate analysis.