PCK1 and Hypoinsulinemia: A potential confounder might be the fetal environment such as hypoglycemia, hypoinsulinemia, intrauterine growth, and/or nutrient restriction, which have been found to induce hepatic PEPCK‐C during late gestation (Philippidis et al. 1972; Torrecilla et al. 2012; Magnusson et al. 2014).