TRPV1 and osteoporosis: Desensitization itself is reported to affect only the nerve-endings and not the non-neural TRPV1 channels (Czikora et al., 2013; Kun et al., 2012; Bíró et al., 1998), but influencing the endovanilloid/endocannabinoid system in chondro- and osteocytes can be involved in bone formation and resorption, although these data are available only on osteoclasts from osteoporosis patients (Rossi et al., 2011).