Multiple lines of evidence support this idea: (i) some of the unassigned transcripts are annotated in other databases different from Encode5, (ii) their TSS is marked by histone modifications associated with active chromatin, (iii) the expression pattern and p53 regulation of several of them has been independently validated and (iv) their expression is suppressed in tumour samples compared with normal tissue. This evidence concerns the gene TP53 and neoplasm.