Particularly melanoma, carcinoma and solid tumors have the most significant enrichment of these genes, including ABCC11 (melanoma drug resistance), SNRNP200 (retinitis pigmentosa), TRERF1 (breast cancer) and WTX (Wilms tumor gene on X chromosome, Wilms tumor) [29–33]. The gene discussed is ENSG00000280371; the disease is Wilms tumor.