ADCYAP1 and Cerebral ischemia: Hypoxia/ischemia-induced PACAP38 upregulation was abolished in neural tissues with decreased HIF-1α activity that resulted from the injection of the HIF-1α-specific inhibitor, 2-ME2; in animals with cerebral ischemia and in a Cre-loxP-based approach to knockout HIF-1α in mice.