At 7 days after cerebral ischemia, the infarct volume and area of the largest infarcted slice as assessed by MRI were significantly reduced in PACAP38-treated mice as compared with those in the groups treated with PACAP38 + GM6001, PACAP38 + PACAP (6–38), or saline (Fig. 5B). The gene discussed is ADCYAP1; the disease is Cerebral ischemia.