TAL1 and acute lymphoblastic leukemia: Therefore, the functional role of SCL, LYL1, and/or LMO2 in regulating self-renewal capacity might be influenced by the immunophenotypic background of the different molecular-genetic subtypes of human T-ALL, a notion that could be tested using transgenic models that overexpress the specific members of this bHLH transcription complex at later stages during T cell development.