Aberrant SERCA expression has been reported to be relevant with the susceptibility and progression of colon cancer, lung cancer and liposarcoma.13, 14, 15, 16, 17, 18, 19, 20, 21 However, the correlation of SERCA2 with the malignance of cervical cancer is not reported before. Here, ATP2A2 is linked to malignant colon neoplasm.