These conditions, however, activate a range of stress response pathways to promote tumor survival and aggressiveness.38 In order to circumvent TRAIL-mediated apoptotic clearance, the expression levels of DR4 and DR5 in many types of cancer cells are nullified, but interestingly, they can be reactivated when cancer cells are challenged with small chemical molecules. This evidence concerns the gene TNFSF10 and neoplasm.