Given that the T17M RHO retinas express pro-inflammatory markersunder the conditions of ER stress, like early mediated IL-1β,and that the photoreceptors could be the sources of these induced cytokines(Figure 2),17 we investigated whether pro-inflammatorycytokines could directly mediate retinal degeneration in the mouse retina.The rationale for this experiment stemmed from the multifunctional nature ofmany cytokines that are activated during inflammation. This evidence concerns the gene IL1B and retinal degeneration.