IL1B and retinal degeneration: However, in either thecase of IL-1β release or the uptake by photoreceptors, it iscapable of promoting photoreceptor cell death, by a mechanism that can beassociated with multiple signaling pathways including inducedneovascularization.38Therefore, we believe that one possible way to trigger retinal degeneration inmice with an activated UPR is to induce overexpression of pro-inflammatorycytokines in the photoreceptors.