Several studies have linked the inverse correlation between HIF-1α and Bim/Bid expression to chemo- and radiotherapy resistance in different types of cancer.26, 28, 29, 36, 37 Consistent with these studies, we could show that knockdown of HIF-1α in MT-2 cells by siRNA led to an increase in Bim and Bid expression and rendered the cells more sensitive to anti-CD95- and TRAIL-induced apoptosis (Figures 5f and g). This evidence concerns the gene BID and cancer.