FLNA and schizophrenia: However, FLNA is one of the novel schizophrenia candidate genes[20] which was involved in the glutamate receptor signaling subnetwork, and might result in brain structure change such as enlargement of the cerebroventricular system, reduced size in cortical region, and abnormal laminar organization with differential genetic changes including abnormal expression of multiple proteins that are involved in cellular functionality such as neuron migration, cell proliferation, axonal outgrowth, and apoptosis[111].