TCHHL1 and neoplasm: Of the tumor-specific mutations, the recurrent mutations with more than two observations were found in the 9 genes encoding TCHHL1, PLXNA2, UNC80, CEP85L, PCLO, NSMCE2, ASXL3, SULF1, and MARS. The frequencies of the tumoral and non-tumoral variants in each patient are highly variable ranging from 8 to 99, and 1 to 147, respectively.