The accumulation of intracellular genomic materials or viruses causes cellular enlargement (Figure 5A, CPB1 + DENV2) and can, therefore, be explained by the accumulation of excessive DENV2 genomic RNA, DENV2 viral proteins and host cell materials [48], in addition to the cytopathic changes that occur during infection [49]. The gene discussed is CPB1; the disease is infection.