Upon LPS stimulation, all groups showed increased IL-10 production, but macrophages from HS produced more of this cytokine (265 pg/mL) than macrophages from HC and HAM/TSP patients (46 pg/mL and 31 pg/mL, respectively, P = 0.003) (Fig. 4B). The gene discussed is IL10; the disease is tropical spastic paraparesis.