Macrophages from HC and HAM/TSP patients produced spontaneously similar levels of CXCL10 (2,458 pg/mL and 2,288 pg/mL) than macrophages from HS (255 pg/mL), After stimulus with LPS, we also did not observed differences between the production of this cytokine by macrophages from HS (2,785 pg/mL), HC (3,418 pg/mL) and HAM/TSP patients (3,201 pg/mL). This evidence concerns the gene CXCL10 and tropical spastic paraparesis.