AZD5363 [(S)-4-amino-N-[1-(4-chlorophenyl)-3-hydroxypropyl]-1-(7H-pyrrolo [2, 3-d] pyrimidin-4-yl) piperidine-4-carboxamide] is a pan-Akt inhibitor that is currently being investigated in phase I clinical trials for cancer therapy (22, 23). The gene discussed is AKT1; the disease is cancer.