TPM3 and myocardial ischemia: In AMI model associated with post LAD ligation for 3 days, 10 proteins involved in the functions of myocardial ischemia stress (i.e. Chloride intracellular channel protein 1 (CICP1); Endoplasmin), cytoskeletal organization (i.e. Tropomyosin alpha-3 chain, tpm3), mitochondria metabolism (i.e. 2-oxoglutarate dehydrogenase, Enoyl-CoA hydratase), redox signaling (i.e. Ribonuclease inhibitor (Rnh1), 14-3-3 protein θ), and acute inflammation (i.e. Serine protease inhibitors A3N, A3K) were identified for the GTPs-mediated cardio-protection against AMI injury (Figure 6).