Polymorphisms in drug target genes (ATP-binding cassette transporter subfamily C member 8 (ABCC8 ) and potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11 ) have recently shown linkage with variability in response to sulfonylurea drugs in T2D cases [34]. The gene discussed is KCNJ11; the disease is type 2 diabetes mellitus.