EZH2 and cancer: In addition to overexpression of EZH2 in cancers, activating mutations and inactivating mutations of EZH2 correlate with certain types of cancer, pointing to the complicated role of EZH2 mutants in cancer meriting further exploration: e.g., whether gain of EZH2 function mutant modulates a set of genes similar to or different from those regulated by inactivating mutation of EZH2.