EZH2 and cancer: Several studies show the small molecule 3-deazaneplanocin A (DZNep), a S-adenosylhomocysteine hydrolase inhibitor, which inhibits methylation reaction and induces EZH2 degradation, suppresses various types of cancer growth and reduce tumor formation: e.g., glioblastoma cancer stem cells, ovarian cancer stem cell-like populations, prostate cancer/cancer stem cells [23].