Recent secondary analysis of the ARDS Clinical Network's (ARDSnet) activated protein C study, where various candidate biomarkers of ARDS were assessed, showed that plasma plasminogen activator inhibitor 1 (PAI-1) and IL-6 were correlated with the oxygenation index (mean airway pressure × FIO2/PaO2). Here, SERPINE1 is linked to acute respiratory distress syndrome.