Impaired GAPDH function was observed in subcellular fractions of fibroblasts from Alzheimer and Huntington patients (37) GAPDH was found to be overexpressed in the neocortex and caudate putamen neurons in a transgenic model of Huntington’s disease (38) The activity of GAPDH, hexokinase and pyruvate kinase was increased in Alzheimer’s disease (AD) (39). Here, GAPDH is linked to early-onset autosomal dominant Alzheimer disease.