Several studies have shown that concomitant administration of antioxidants, SOD mimetic, anti-inflammatory agents, ETA, and AT-1 receptor blockers, all of them reducing the levels of ROS formation and/or blocking the downstream signaling pathways induced by CIH, effectively prevents the enhanced CB chemosensory as well as the development of the hypertension. This evidence concerns the gene SOD1 and Hypertension.