We and other have proposed that ET-1 is involved in the potentiation of the CB chemosensory discharge induced by CIH (Rey et al., 2006, 2007; Pawar et al., 2009; Iturriaga, 2013; Peng et al., 2013) and in the development of hypertension (Troncoso Brindeiro et al., 2007; Allahdadi et al., 2008). Here, EDN1 is linked to hypertensive disorder.