This together with observations indicating that the profibrogenic activity of AT1R in ethanol induced liver fibrosis requires the presence of CB1R (Rozenfeld et al., 2011) suggest that the CB1R-AT1R heteromer represents a novel therapeutic target for the treatment of liver fibrosis and that the CB1R-AT1R heteromer by its ability to block the secretion of fibrogenic proteins could potentially be used as a therapeutic to treat liver fibrosis. Here, CNR1 is linked to Hepatic fibrosis.