Activation of c-Raf caused by BRAF inhibitors in tumors with activated Ras has been shown, paradoxically, to stimulate, rather than inhibit MAPK pathway signaling and is suspected of causing new skin cancers that have been observed as a frequent side effect of BRAF inhibitors (Hall-Jackson et al., 1999; Hatzivassiliou et al., 2010; Heidorn et al., 2010; Poulikakos et al., 2010). Here, BRAF is linked to skin neoplasm.