BRCA2 and neoplasm: For example PARP inhibitors were demonstrated to be synthetic lethal in vitro with mutations in the tumor suppressors BRCA1 and BRCA2 (Farmer et al., 2005; McCabe et al., 2005) and clinical testing has established the same genetic dependence on tumor sensitivity to the PARP inhibitor olaparib in patients (Fong et al., 2009).