TJP1 and intracranial embolism: In brain cECs a decrease in the expression of ZO-1 and occludin after cerebral embolism has been reported (Kago et al., 2006) and in vitro under hypoxic conditions the localization of ZO-1 and ZO-2 was altered with a concurrent decrease in TEER (Mark and Davis, 2002; Fischer et al., 2004).