SPINK5 and Netherton syndrome: The positive upper epidermal immunostaining for protein LEKTI, the absence of transglutaminase-1 or corneodesmosin gene mutations, excluded genodermatoses such as Netherton’ syndrome, autosomal recessive congenital ichthyoses [12] or inflammatory peeling skin syndrome [13], whereas the detection of HLA-Cw*06 in both twins, as susceptibility locus, was strongly consistent with an early-onset psoriasis [14], but the clinical picture and the absence of IL-36 receptor antagonist gene mutations excluded a deficiency of interleukin 36–receptor antagonist also called DITRA syndrome [15].